Renal disease and digoxin immunoassays.
نویسندگان
چکیده
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منابع مشابه
Improved interassay correlation of digoxin results in patients with and without renal failure by elimination of digoxin-like immunoreactive factors.
Use of immunoassays that do not detect endogenous digoxin-like immunoreactive factors (DLIF) in serum significantly improves the between-assay correlation of digoxin results for patients. We investigated five different immunoassay methods (Abbott, Clinical Assays, Corning, Du Pont, and Syva), measuring digoxin by all five assays in sera from 38 patients in renal failure and in 40 patients with ...
متن کاملMonitoring of unbound digoxin in patients treated with anti-digoxin antigen-binding fragments: a model for the future?
Digoxin is one of the few therapeutic drugs for which antidotal therapy is available (1). Administration of Fab fragments has successfully been used to reverse the effects of life-threatening digoxin overdoses for over 20 years. Digoxin-specific Fab fragments are produced by cleaving sheep digoxin-specific IgG with papain to form two Fab fragments (50 000 Da each) and one 50 000-Da Fc fragment ...
متن کاملEndogenous digoxin-like immunoreactive factors: impact on digoxin measurements and potential physiological implications.
Various laboratories have reported endogenous digoxin-like immunoreactive factor(s) (DLIF) in blood from patients in renal failure or liver failure, from newborn infants, and from third-trimester pregnant women. Similar immunoreactivity has been detected in amniotic fluid, in cord blood, and in urine and serum from normal subjects. The factor(s) giving rise to this immunoreactivity cross react ...
متن کاملEffect of Indian Ayurvedic medicine Ashwagandha on measurement of serum digoxin and 11 commonly monitored drugs using immunoassays: study of protein binding and interaction with Digibind.
CONTEXT Ashwagandha, a popular Ayurvedic medicine, is now available in the United States. Alkaloids found in this herb have structural similarity with digoxin. OBJECTIVE To study potential interference of Ashwagandha with serum digoxin measurement by immunoassays. Potential interference was also investigated with immunoassays for 11 other commonly monitored drugs. In addition, interaction of ...
متن کاملAbbott TDx, Dade Stratus, and Du Pont aca automated digoxin immunoassays compared with a reference radioimmunoassay method.
Automated digoxin immunoassays with the Abbott TDx, Dade Stratus, and Du Pont aca were evaluated against an RIA similar to the Centers for Disease Control Candidate Reference Method. All three automated methods correlated poorly with the reference method. Particularly disconcerting were the falsely increased values (up to 0.6 micrograms/L) obtained by the Stratus for blank specimens. We discuss...
متن کاملEffect of antibody specificity on results of selected digoxin immunoassays among various clinical groups.
We examined the specificity of three automated digoxin immunoassays (Abbott TDxFLx Digoxin II assay, Baxter-Dade Stratus II Digoxin assay, and Ciba Corning ACS Digoxin assay) applied without modification to (a) sera from 229 digoxin-free patients in 12 cohorts associated with nonspecific or endogenous digoxin-like immunoreactive factor (DLIF) interference, and (b) drug-free serum supplemented w...
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ورودعنوان ژورنال:
- British medical journal
دوره 291 6505 شماره
صفحات -
تاریخ انتشار 1985